Description
Rebeglo-20 Injection contains Rabeprazole 20 mg, a fast-acting proton pump inhibitor (PPI) used for effective control of gastric acid secretion in acute care settings. It is ideal when oral administration is not feasible.
Composition
- Rabeprazole Sodium equivalent to Rabeprazole – 20 mg
- Lyophilized sterile powder for reconstitution (IV use only)
Mechanism of Action
Rabeprazole works by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme (gastric proton pump) in parietal cells, thereby blocking the final step of acid production and ensuring sustained acid suppression.
Indications
Rebeglo-20 is indicated for:
- Gastroesophageal Reflux Disease (GERD)
- Peptic ulcer disease (gastric & duodenal ulcers)
- Erosive esophagitis
- Zollinger–Ellison syndrome
- Stress ulcer prophylaxis in critically ill patients
- Upper gastrointestinal bleeding
Dosage & Administration
- Administered via intravenous injection or infusion
- Typical dose: 20 mg once daily or as prescribed
- Switch to oral therapy when clinically appropriate
For hospital use under medical supervision only.
Key Benefits
- Rapid onset of acid suppression
- Effective in emergency and ICU settings
- Helps in ulcer healing and bleeding control
- Suitable alternative when oral PPIs cannot be used
Precautions
- Use cautiously in hepatic impairment
- Long-term use may cause vitamin B12 deficiency
- Monitor magnesium levels during prolonged therapy
- Rule out gastric malignancy before extended use
Possible Side Effects
- Headache
- Nausea, vomiting
- Diarrhea or constipation
- Injection site reactions
- Rare: hypersensitivity reactions
Storage
- Store below 25°C, protected from light
- Use immediately after reconstitution
Packaging
- Available as 20 mg sterile lyophilized vial
