Pantoprazole for Injection BP 40 mg (Pancare 40)

Description

Pancare 40 contains Pantoprazole 40 mg, a widely used proton pump inhibitor (PPI) designed for intravenous administration. It is indicated for the short-term treatment of acid-related disorders when oral therapy is not feasible.

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Composition

• Pantoprazole Sodium BP equivalent to Pantoprazole – 40 mg
• Sterile powder for reconstitution (IV use)

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Mechanism of Action

Pantoprazole works by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme (proton pump) in gastric parietal cells, thereby reducing gastric acid secretion and promoting healing of acid-related damage.

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Indications

Pancare 40 is used in:

• Gastroesophageal Reflux Disease (GERD)
• Peptic ulcer disease (gastric & duodenal ulcers)
• Erosive esophagitis
• Zollinger–Ellison syndrome
• Prevention and treatment of stress ulcers in critically ill patients
• Upper GI bleeding management

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Dosage & Administration

• Administered via intravenous injection or infusion
• Common adult dose: 40 mg once daily (may vary based on condition)
• Switch to oral therapy as soon as clinically appropriate

To be administered under medical supervision only.

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Key Benefits

• Rapid acid suppression in emergency and ICU settings
• Suitable when oral administration is not possible
• Helps prevent stress-related mucosal damage
• Well-tolerated with a strong safety profile

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Precautions

• Long-term use may lead to vitamin B12 deficiency
• Use cautiously in severe liver impairment
• Rule out gastric malignancy before prolonged therapy
• Monitor for hypomagnesemia in extended use

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Possible Side Effects

• Headache
• Diarrhea or constipation
• Nausea
• Injection site reactions
• Rare: allergic reactions, electrolyte imbalance

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Storage

• Store below 25°C, protected from light
• Use immediately after reconstitution

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Packaging

• Available as 40 mg sterile vial