Rabeprazole for Injection (Syber 20)
Description
Syber 20 Injection contains Rabeprazole 20 mg, a potent proton pump inhibitor (PPI) designed for intravenous administration. It provides rapid and sustained suppression of gastric acid, making it ideal for acute and hospital-based care.
Composition
- Rabeprazole Sodium equivalent to Rabeprazole – 20 mg
- Lyophilized sterile powder for reconstitution
- For IV use only
Mechanism of Action
Rabeprazole works by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme (gastric proton pump) in parietal cells, thereby blocking the final step of acid secretion and promoting healing of acid-related conditions.
Indications
Syber 20 is indicated for:
- Gastroesophageal Reflux Disease (GERD)
- Peptic ulcer disease (gastric & duodenal ulcers)
- Erosive esophagitis
- Zollinger–Ellison syndrome
- Stress ulcer prophylaxis in critically ill patients
- Upper gastrointestinal bleeding
Dosage & Administration
- Administered via intravenous injection or infusion
- Typical adult dose: 20 mg once daily, or as directed
- Switch to oral therapy when clinically appropriate
To be administered under medical supervision only.
Key Benefits
- Rapid onset of action for acid control
- Effective in emergency and ICU settings
- Helps in ulcer healing and bleeding management
- Suitable alternative when oral PPIs are not feasible
Precautions
- Use cautiously in hepatic impairment
- Long-term use may lead to vitamin B12 deficiency
- Monitor magnesium levels during prolonged therapy
- Rule out gastric malignancy before extended use
Possible Side Effects
- Headache
- Nausea, vomiting
- Diarrhea or constipation
- Injection site reactions
- Rare: hypersensitivity reactions
Storage
- Store below 25°C, protected from light
- Use immediately after reconstitution
Packaging
- Available as 20 mg lyophilized sterile vial
